We’re scaring ourselves by thinking about the molds that are found in pet food. We’ve discussed Zearalenone, which causes estrogenism, and now, let’s consider Fumoninsin. Fumoninsin is product of the mold Fusarium. Fumoninsin is found in moldy corn , wheat, and sorghum. It causes cancer, kidney and liver disease, cardiac disease, central nervous system disease (especially in horses) and respiratory disease(especially in pigs). In humans, fumoninsin is associated with high rates of esophageal cancer. On a cellular level, fumonisin releases free radicals that cause oxidative stress and lipid peroxidation. In the developing fetus, especially when the mother is folate deficient, fumoninsin causes neural tube defect so babies can be born without brains or with spina bifida. In horses, fumoninsin causes softening of the tissues in the brain (leukoencephalomalacia). It can also cause apathy, changes in temperament, inco-ordination, walking into objects, and paralysis of the lips and tongue. When I see Gator, the Airedale, who had a sudden onset of head pressing after eating a grain-based treat, we’re going to consider fumoninsin toxicity. Blood and urine tests will help evaluate Gator's liver and kidneys. As bright as Airedales are, it will be difficult to pick up damage to her beautiful brain.
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